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Potentiation of bradykinin with synthetic peptides on guinea pig ileum
1981 (English)In: International journal of peptide and protein research, ISSN 0367-8377, Vol. 18, no 1, 61-68 p.Article in journal (Refereed) Published
Abstract [en]

Potentiation of the activity of bradykinin on the isolated guinea pig ileum was studied using a designed test system with the synthetic peptides Leu-Val-Glu-Ser-Ser-Lys, Thr-Pro-Val-Ser-Glu-Lys, derivatives of the former coupled to the N- and C-terminals of bradykinin and two peptides with phenylalanine substituted with its isomer L-3-amino-3-phenylpropanoic acid in the 5- and 5,8-positions in bradykinin respectively. On average, two times potentiation effects were obtained at 10-6 to 10-8 M concentrations of the peptides. After elimination of the basic lysine no potentiation occurred with synthetic Leu-Val-Glu-Ser-Ser. With the [beta Phe5,8]-bradykinin a mixed sensitizing/potentiating effect was observed, suggesting that a separation of the two effects may be difficult with an intact receptor structure of this kind. This peptide was not hydrolyzed by carboxypeptidase B or chymotrypsin.

Place, publisher, year, edition, pages
1981. Vol. 18, no 1, 61-68 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-169931PubMedID: 7309368OAI: oai:DiVA.org:uu-169931DiVA: diva2:508052
Available from: 2012-03-07 Created: 2012-03-07 Last updated: 2012-03-30Bibliographically approved

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Syvänen, Ann-Christine
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