Kininogen in factor VIII-deficient plasma (haemophilia A)
1981 (English)In: Thrombosis Research, ISSN 0049-3848, E-ISSN 1879-2472, Vol. 24, no 4, 275-284 p.Article in journal (Refereed) Published
The HMr and LMr molecular forms of kininogen were found to occur in normal distribution in plasma from a patient with severe haemophilia A. Present findings indicate that lack of Factor VIII does not influence, the normal content and distribution of immunoreactive kininogens determined by single radial immunodiffusion and radioimmunoassay. The partially purified HMr and LMr kininogens were antigenically identical with the kininogens in normal human plasma determined using the monospecific antisera raised in rabbits against purified kininogen antigens. Low kallikrein activity on H-D-Pro-Phe-Arg-pNA in the haemophilic plasma was apparently due to preparative procedures. This concept is supported by the normal binding ratio of trypsin to pure α2-macroglobulin isolated from the haemophilic plasma.
Place, publisher, year, edition, pages
1981. Vol. 24, no 4, 275-284 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-169928DOI: 10.1016/0049-3848(81)90001-3PubMedID: 6175039OAI: oai:DiVA.org:uu-169928DiVA: diva2:508055