uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Differential actions of neurotrophins in the locus coeruleus and basal forebrain.
Show others and affiliations
1993 (English)In: Experimental Neurology, ISSN 0014-4886, E-ISSN 1090-2430, Vol. 119, no 1, 72-8 p.Article in journal (Refereed) Published
Abstract [en]

The neurotrophin gene family, including nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and NT-4/NT-5, supports the survival of distinct peripheral neurons, however, actions upon central neurons are relatively undefined. In this study we have compared different neurotrophins in the regulation of neuronal survival and function using dissociated embryonic cell cultures from two brain regions, the basal forebrain (BF) and locus coeruleus (LC). In the BF, NGF increased choline acetyl transferase (ChAT) activity, but did not influence cholinergic cell survival. In contrast to NGF, BDNF, NT-3, and the novel neurotrophin, NT-4, all increased ChAT activity and cholinergic cell survival. We also examined embryonic LC neurons in culture. LC neurons are unresponsive to NGF. In contrast, NT-3 and NT-4 elicited significant increases in survival of noradrenergic LC neurons, the first demonstration of trophic effects in this critical brain region. Identification of factors supporting coeruleal and basal forebrain neuronal survival may provide insight into mechanisms mediating degeneration of these disparate structures in clinical disorders.

Place, publisher, year, edition, pages
1993. Vol. 119, no 1, 72-8 p.
National Category
URN: urn:nbn:se:uu:diva-170016DOI: 10.1006/exnr.1993.1007PubMedID: 8432352OAI: oai:DiVA.org:uu-170016DiVA: diva2:508176
Available from: 2012-03-07 Created: 2012-03-07 Last updated: 2012-03-07

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Hallböök, F
In the same journal
Experimental Neurology

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 256 hits
ReferencesLink to record
Permanent link

Direct link