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Anti-schistosomiasis triterpene glycoside from the Egyptian medicinal plant Asparagus stipularis
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Division of Pharmacognosy. (Göransson)
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2012 (English)In: Revista Brasileira de Farmacognosia, ISSN 0102-695X, Vol. 22, no 2, 314-318 p.Article in journal (Refereed) Published
Abstract [en]

Bioassay-guided isolation using an in vitro assay testing for anti-schistosomiasis yielded a novel triterpene saponin, asparagalin A, from the n-butanol extract of the roots of Asparagus stipularis Forssk., Asparagaceae. The structure was elucidated by spectroscopic analysis and chemical transformations. Administration of asparagalin A resulted in a retardation of worm growth and locomotion at the first day and showed a significant activity of egg-laying suppression at 200 mu g/mL concentration.

Place, publisher, year, edition, pages
2012. Vol. 22, no 2, 314-318 p.
Keyword [en]
Anti-schistosomiasis, Asparagus stipularis, Asparagaceae, triterpene glycoside
National Category
Natural Sciences
Identifiers
URN: urn:nbn:se:uu:diva-170143DOI: 10.1590/S0102-695X2012005000004ISI: 000299742200010OAI: oai:DiVA.org:uu-170143DiVA: diva2:508523
Available from: 2012-03-08 Created: 2012-03-08 Last updated: 2012-03-19Bibliographically approved

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