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New insights into the pathobiology of chronic lymphocytic leukemia
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Hematology and Immunology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Hematology and Immunology.
2011 (English)In: Journal of Hematopathology, ISSN 1868-9256, Vol. 4, no 3, 149-163 p.Article, review/survey (Refereed) Published
Abstract [en]

Chronic lymphocytic leukemia (CLL) is a heterogeneous disease with a varying clinical outcome; however, the pathogenic mechanisms involved in disease development have remained largely unknown. In recent years, novel biomarkers, such as certain recurrent genomic alterations and the immunoglobulin heavy variable gene mutational status, have significantly improved the subdivision of the disease along with the prognostic assessment of individual patients. Advanced molecular studies have also revealed important genetic/epigenetic events and potential susceptibility loci for CLL, as well as implicating antigens in CLL development. Furthermore, the presence of monoclonal B cell lymphocytosis (MBL) has been demonstrated to precede CLL and appears to be a pre-leukemic condition. In this review, we will not only focus on recent developments made in the fields of genetics and immunogenetics in CLL, but also provide a brief overview of MBL, since we believe that advancements in these areas will have a major impact on our understanding of CLL pathobiology.

Place, publisher, year, edition, pages
2011. Vol. 4, no 3, 149-163 p.
National Category
Medical Genetics
Identifiers
URN: urn:nbn:se:uu:diva-170390DOI: 10.1007/s12308-011-0091-yOAI: oai:DiVA.org:uu-170390DiVA: diva2:509067
Available from: 2012-03-12 Created: 2012-03-12 Last updated: 2012-03-12Bibliographically approved

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