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Erythrocyte aspartate aminotransferase activity as a possible indirect marker for stimulated erythropoiesis in male and female athletes
Charité – Campus Benjamin Franklin, Centre of Trauma and Reconstructive Surgery, Berlin, Germany.
2007 (English)In: Laboratory Hematology, ISSN 1080-2924, E-ISSN 1523-6528, Vol. 13, no 2, 49-55 p.Article in journal (Refereed) Published
Abstract [en]

A reliable and cost-effective screening test for erythropoietin (EPO) doping is still unavailable. Thus a new approach by estimating mean red blood cell (RBC) age by means of erythrocyte aspartate aminotransferase activity (eAST) was developed. We investigated 201 women and 169 men residing at low altitude for peak oxygen uptake, EPO, and eAST. Additionally, we investigated 63 women and 42 men residing at 2600 m above sea level for EPO and eAST. Furthermore, 22 female and 28 male patients with renal failure receiving recombinant human EPO (rhEPO) were investigated for eAST levels. There was no difference in eAST between trained (women, 2.9+/-0.7 U x gHb(-1); men, 2.5+/-0.4 U x gHb(-1)), moderately trained (women, 2.8+/-0.6 U x gHb(-1); men, 2.4+/-0.4 U x gHb(-1)), and untrained subjects (women, 3.0+/-0.5 U x gHb(-1); men, 2.5+/-0.4 U.gHb-1) at low altitude. Participants receiving rhEPO had a dose-dependent increase in eAST (r=0.25; P< .05). Trained high-altitude residents (women, 2.8+/-0.8 U x gHb(-1); men, 3.0+/-1.1 U x gHb(-1)) had higher eAST than untrained high-altitude residents (women, 2.5+/-0.6 U.gHb-1; men, 2.4+/-0.4 U x gHb(-1); P< .05). Since eAST was sensitive to RBC rejuvenation, eAST elevation could indicate EPO use in lowlanders. eAST values above the 95% confidence interval (>3.3 U x gHb(-1) for men; >4.1 U x gHb(-1) for women) are suspected of EPO use.

Place, publisher, year, edition, pages
2007. Vol. 13, no 2, 49-55 p.
Keyword [en]
sports, EPO, doping, erythropoiesis, red blood cells
National Category
Sport and Fitness Sciences Physiology
Identifiers
URN: urn:nbn:se:uu:diva-170588DOI: 10.1532/LH96.07005PubMedID: 17573281OAI: oai:DiVA.org:uu-170588DiVA: diva2:509331
Available from: 2012-03-13 Created: 2012-03-12 Last updated: 2017-12-07Bibliographically approved

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Robinson, Yohan

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