uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Erythropoiesis in multiply injured patients
Charité – Campus Benjamin Franklin, Klinik für Unfall- und Wiederherstellungschirurgie, Berlin.
Show others and affiliations
2006 (English)In: Journal of Trauma, ISSN 0022-5282, E-ISSN 1529-8809, Vol. 61, no 5, 1285-1291 p.Article, review/survey (Refereed) Published
Abstract [en]

Posttraumatic anemia in multiply injured patients is caused by hemorrhage, reduced red blood cell survival, and impaired erythropoiesis. Trauma-induced hyperinflammation causes impaired bone-marrow function by means of blunted erythropoietin (EPO) response, reduced iron availability, suppression and egress of erythroid progenitor cells. To treat posttraumatic anemia in severely injured patients, symptomatic therapy by blood transfusion is not sufficient. Furthermore, EPO, iron, and the use of red cell substitutes should be considered. The posttraumatic systemic inflammatory response syndrome (SIRS) induces posttraumatic anemia. Thus, a worsening of SIRS by a "second-hit" through blood transfusion ought to be avoided.

Place, publisher, year, edition, pages
2006. Vol. 61, no 5, 1285-1291 p.
Keyword [en]
trauma, anemia, erythropoietin, erythropoiesis, systemic inflammatory response syndrome
National Category
Surgery Hematology
URN: urn:nbn:se:uu:diva-170591DOI: 10.1097/01.ta.0000240969.13891.9bPubMedID: 17099548OAI: oai:DiVA.org:uu-170591DiVA: diva2:509333
Available from: 2012-03-13 Created: 2012-03-12 Last updated: 2012-03-13Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Robinson, Yohan
In the same journal
Journal of Trauma

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 148 hits
ReferencesLink to record
Permanent link

Direct link