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PAI-1 level and the PAI-1 4G/5G polymorphism in relation to risk of non-fatal myocardial infarction: results from the Stockholm Heart Epidemiology Program (SHEEP).
Uppsala University, Disciplinary Domain of Medicine and Pharmacy. (Preventivmedicin)
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2003 (English)In: Thrombosis and Haemostasis, ISSN 0340-6245, Vol. 89, no 6, 1064-71 p.Article in journal (Refereed) Published
Abstract [en]

This study examines the relationship between plasma Plasminogen Activator Inhibitor-1 (PAI-1) activity and the PAI-1 4G/5G polymorphism, and their association with the risk of myocardial infarction (MI). Furthermore, this study explores whether a high level of PAI-1 or whether the PAI-1 4G/5G polymorphism synergistically interacts with any established environmental risk factor for MI. This case-referent study of subjects aged 45-70 and living in Stockholm includes 851 men and 361 women with first-time MI and 1051 men and 505 women who were randomly chosen as referents from a population register. The adjusted odds ratio (OR) of MI was 1.9 (95% confidence interval [CI] 1.4-2.8) for men with a plasma PAI-1 activity level greater than the 90 th percentile value of referents. The corresponding OR for women was 1.5 (95% CI 0.9-2.5). A strong indication of synergistic interaction was found in men for the co-exposure to high plasma PAI-1 activity and current smoking, an adjusted synergy index score of 3.9 (95% CI 1.2-13.2). In women, the 4G allele was associated slightly with an increased risk of MI, OR 1.4 (95% CI 1.0-1.9). This association was not found in men. There were no clear indications of synergistic interaction effects involving the PAI-1 4G/5G polymorphism and the environmental exposures considered (cigarette smoking, physical inactivity, overweight, diabetes mellitus, hypercholesterolaemia, hypertension, high C-reactive protein and hypertriglyceridaemia).

Place, publisher, year, edition, pages
2003. Vol. 89, no 6, 1064-71 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-170691DOI: 10.1267/THRO03061064PubMedID: 12783120OAI: oai:DiVA.org:uu-170691DiVA: diva2:509385
Available from: 2012-03-12 Created: 2012-03-12 Last updated: 2012-03-12

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