uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
How to evaluate interaction between causes: a review of practices in cardiovascular epidemiology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy. (Preventivmedicin)
1996 (English)In: Journal of Internal Medicine, ISSN 0954-6820, E-ISSN 1365-2796, Vol. 239, no 5, 377-82 p.Article in journal (Refereed) Published
Abstract [en]

To increase the knowledge of interaction or synergy between risk factors in an important task in medical research. Still, current literature in cardiovascular epidemiology reflects major misconceptions as how to evaluate interaction. This paper presents Rothman's model of causation from which strict empirical criteria of interaction can be derived. In principle, the method to apply consists of comparing risk differences for one risk factor of interest across strata of the other. Commonly used but incorrect approaches are exemplified and discussed. These include reporting risk of disease among those with combined exposure, comparing relative risks for one exposure after stratification by level of the other, and including an interaction term in the regression model and drawing conclusions from its P-value.

Place, publisher, year, edition, pages
1996. Vol. 239, no 5, 377-82 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-170718PubMedID: 8642229OAI: oai:DiVA.org:uu-170718DiVA: diva2:509427
Available from: 2012-03-12 Created: 2012-03-12 Last updated: 2012-03-12

Open Access in DiVA

No full text


Search in DiVA

By author/editor
Hallqvist, Johan
By organisation
Disciplinary Domain of Medicine and Pharmacy
In the same journal
Journal of Internal Medicine
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 186 hits
ReferencesLink to record
Permanent link

Direct link