Differential effect of PYY1-36 and PYY3-36 on gastric emptying in man
2009 (English)In: Regulatory Peptides, ISSN 0167-0115, E-ISSN 1873-1686, Vol. 158, no 1-3, 57-62 p.Article in journal (Refereed) Published
Peptide tyrosine-tyrosine (PYY) is a prandially controlled hormone in endocrine ileal and colonic mucosa cells. In plasma, PYY appears as full-length PYY1-36 and truncated PYY3-36. Both have different pharmacological profile, and PYY3-36 seems to inhibit food intake. We aimed at investigating the effect of intravenously administered PYY1-36 and PYY3-36 on gastric emptying and short-term metabolic control. Eight healthy adults were studied in single-blinded, randomized design. At separate occasions, intravenous infusion of saline, PYY1-36 or PYY3-36 (0.8 pmol kg− 1 min− 1) and a radio-labelled omelette were given. Gastric emptying (scintigraphy), appetite ratings (VAS), and plasma concentrations of insulin, glucose, GLP-1 and PYY were measured. PYY3-36 and PYY1-36 both inhibited gastric emptying, PYY3-36 most effectively. Half-emptying time was prolonged from 63.1 ± 5.2 (saline) to 87.0 ± 11.5 min (PYY3-36), whereas retention at 120 min was 2.5 ± 1.4% for saline, 10.7 ± 4.4 for PYY1-36 and 15.8 ± 4.4 for PYY3-36. Neither form influenced glucose or GLP-1 concentrations, but both decreased the postprandial rise in insulin. PYY3-36 induced nausea (VAS increase 47.5 ± 22.6 mm) and decreased prospective consumption (VAS change 39.5 ± 7.7 mm). In conclusion, PYY3-36's reducing effect upon food intake might be mediated by a decreased gastric emptying rate.
Place, publisher, year, edition, pages
2009. Vol. 158, no 1-3, 57-62 p.
Gut hormones, Motility, Gastric emptying
Gastroenterology and Hepatology
Research subject Medical Science
IdentifiersURN: urn:nbn:se:uu:diva-170767DOI: 10.1016/j.regpep.2009.07.013PubMedID: 19651163OAI: oai:DiVA.org:uu-170767DiVA: diva2:509477