uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Metastatic colorectal cancer: Current treatment and future options for improved survival : Medical approach - present status
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Oncology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Oncology.
2012 (English)In: Scandinavian Journal of Gastroenterology, ISSN 0036-5521, Vol. 47, no 3, 296-314 p.Article in journal (Refereed) Published
Abstract [en]

Background. Metastatic colorectal cancer has a poor prognosis, and the majority of patients are left with palliative measures. The development seen using medical treatments are reviewed.

Material and methods. A systematic approach to the literature-based evidence of effects from palliative chemotherapy and targeted drugs was aimed at.

Results. The continuous improvements during the past 20-25 years have been documented in several large conclusive trials. At the end of the 1980s, the evidence that chemotherapy should be used at all was very limited, whereas presently most patients can be offered three lines of chemotherapy with or without a targeted drug based upon good scientific evidence. Median survival in trials has gradually improved from about 6 months to above 24 months in the most recent trials. Survival in the populations has, however, not improved to the same extent. Several important issues remain to be solved, such as the best sequence of treatments, what regimens to use in various situations, when to start and when to stop if a response is seen, whether cure may be possible in a small subset of patients, and socioeconomic issues. Integration of surgery and other local methods have further improved outcome for some individuals, but must be fine-tuned.

Conclusions. Progress has been rapid in advanced colorectal cancer. This is likely a result of well-designed trials in collaboration between academy and industry, showing a great interest in the disease. A multi-professional approach and future collaborations may hopefully introduce new treatment concepts, further improving outcome.

Place, publisher, year, edition, pages
2012. Vol. 47, no 3, 296-314 p.
Keyword [en]
advanced colorectal cancer, chemotherapy, palliation, targeted drugs
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-170319DOI: 10.3109/00365521.2012.640828ISI: 000300436000006OAI: oai:DiVA.org:uu-170319DiVA: diva2:509514
Available from: 2012-03-13 Created: 2012-03-12 Last updated: 2012-03-13Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Glimelius, BengtCavalli-Bjorkman, Nina
By organisation
In the same journal
Scandinavian Journal of Gastroenterology
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 192 hits
ReferencesLink to record
Permanent link

Direct link