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Evaluation of the blood compatibility of materials, cells and tissues: Basic concepts, test models and practical guidelines
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical Immunology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical Immunology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical Immunology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical Immunology.
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2013 (English)In: Advances in Experimental Medicine and Biology, ISSN 0065-2598, E-ISSN 2214-8019, Vol. 735, 257-270 p.Article in journal (Refereed) Published
Abstract [en]

Medicine today uses a wide range of biomaterials, most of which make contact with blood permanently or transiently upon implantation. Contact between blood and nonbiological materials or cells or tissue of nonhematologic origin initiates activation of the cascade systems (complement, contact activation/coagulation) of the blood, which induces platelet and leukocyte activation.

Although substantial progress regarding biocompatibility has been made, many materials and medical treatment procedures are still associated with severe side effects. Therefore, there is a great need for adequate models and guidelines for evaluating the blood compatibility of biomaterials. Due to the substantial amount of cross talk between the different cascade systems and cell populations in the blood, it is advisable to use an intact system for evaluation.

Here, we describe three such in vitro models for the evaluation of the biocompatibility of materials and therapeutic cells and tissues. The use of different anticoagulants and specific inhibitors in order to be able to dissect interactions between the different cascade systems and cells of the blood is discussed. In addition, we describe two clinically relevant medical treatment modalities, the integration of titanium implants and transplantation of islets of Langerhans to patients with type 1 diabetes, whose mechanisms of action we have addressed using these in vitro models.

Place, publisher, year, edition, pages
2013. Vol. 735, 257-270 p.
National Category
Immunology in the medical area Microbiology in the medical area
Identifiers
URN: urn:nbn:se:uu:diva-170925DOI: 10.1007/978-1-4614-4118-2_18ISI: 000333837700019OAI: oai:DiVA.org:uu-170925DiVA: diva2:509749
Available from: 2012-03-13 Created: 2012-03-13 Last updated: 2017-05-04Bibliographically approved

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Nilsson Ekdahl, KristinaHong, JaanLarsson, RolfNilsson, Bo

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Immunology in the medical areaMicrobiology in the medical area

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