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Symmetric halogen bonding is preferred in solution
Department of Chemistry and Molecular Biology, University of Gothenburg, Sweden.
Department of Chemistry and Molecular Biology, University of Gothenburg, Sweden.
Department of Chemistry and Molecular Biology, University of Gothenburg, Sweden.
Department of Chemistry and Molecular Biology, University of Gothenburg, Sweden.
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2012 (English)In: Journal of the American Chemical Society, ISSN 0002-7863, E-ISSN 1520-5126, Vol. 134, no 12, 5706-5715 p.Article in journal (Refereed) Published
Abstract [en]

Halogen bonding is a recently rediscovered secondary interaction that shows potential to become a complementary molecular tool to hydrogen bonding in rational drug design and in material sciences. Whereas hydrogen bond symmetry has been the subject of systematic studies for decades, the understanding of the analogous three-center halogen bonds is yet in its infancy. The isotopic perturbation of equilibrium (IPE) technique with 13C NMR detection was applied to regioselectively-deuterated pyridine complexes to investigate the symmetry of [N–I–N]+ and [N–Br–N]+ halogen bonding in solution. Preference for a symmetric arrangement was observed for both a freely adjustable and for a conformationally restricted [N–X–N]+ model system, as also confirmed by computation on the DFT level. A closely attached counter ion is shown to be compatible with the preferred symmetric arrangement. The experimental observations and computational predictions reveal a high energetic gain upon formation of symmetric, three-center four-electron halogen bonding. Whereas hydrogen bonds are generally asymmetric in solution and symmetric in the crystalline state, the analogous bromine and iodine centered halogen bonds prefer symmetric arrangement in solution.

Place, publisher, year, edition, pages
American Ceramic Society, 2012. Vol. 134, no 12, 5706-5715 p.
National Category
Chemical Sciences
Identifiers
URN: urn:nbn:se:uu:diva-171142DOI: 10.1021/ja301341hISI: 000302489500051OAI: oai:DiVA.org:uu-171142DiVA: diva2:510260
Available from: 2012-03-15 Created: 2012-03-15 Last updated: 2017-12-07Bibliographically approved

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Bergquist, Jonas

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