Involvement of inflammation in normal pregnancy
2013 (English)In: Acta Obstetricia et Gynecologica Scandinavica, ISSN 0001-6349, E-ISSN 1600-0412, Vol. 92, no 5, 601-605 p.Article in journal (Refereed) Published
To study the role of inflammatory biomarkers of cytokine and cyclooxygenase origin throughout normal pregnancy and postpartum.
Longitudinal prospective study.
One outpatient antenatal clinic in Uppsala, Sweden.
Thirty-seven healthy women with normal pregnancies and normal neonatal outcome were included.
Blood and urine samples were collected from each woman at least 6 times during pregnancy and postpartum. Plasma levels of IL-6 and TNF-α were measured by using ELISA kits and urine levels of PGF2α metabolite were measured by using RIA.
Main outcome measures.
Median plasma and urine levels, the 25:th to the 75:th percentile and the average change per gestational week of IL-6, TNF-α and PGF2α metabolite .
IL-6 levels increased significantly throughout pregnancy and postpartum levels remained high. No change in TNF-α could be seen with advancing gestational age or postpartum period. The PGF2α metabolite levels increased significantly throughout pregnancy and decreased in postpartum period.
These results suggest that mild but significant inflammatory activity is involved in development of normal pregnancy and might have important physiological effects.
Place, publisher, year, edition, pages
2013. Vol. 92, no 5, 601-605 p.
IL-6, Inflammation, Pregnancy, TNF-α and PGF2α
Obstetrics, Gynecology and Reproductive Medicine
Research subject Obstetrics and Gynaecology
IdentifiersURN: urn:nbn:se:uu:diva-171156DOI: 10.1111/aogs.12093ISI: 000319060200016PubMedID: 23506129OAI: oai:DiVA.org:uu-171156DiVA: diva2:510294