uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Muscle biopsies in children: an evaluation of histopathology and clinical value during a 5-year period
Show others and affiliations
2009 (English)In: Upsala Journal of Medical Sciences, ISSN 0300-9734, E-ISSN 2000-1967, Vol. 114, no 1, 41-45 p.Article in journal (Refereed) Published
Abstract [en]

Muscle biopsy is an important diagnostic tool in the investigation of children with neuromuscular disorders. This report presents the experience with paediatric muscle biopsies during a 5-year period at a routine pathology laboratory. A total number of 58 cases were included, and indications, microscopical findings, and final histopathological diagnoses were recorded. A total of 21 biopsies were from females (36%) and 37 biopsies from males (64%); 53% of the cases were from children under 2 years of age. Major pathological findings were found in 30% comprising muscular dystrophy, neurogenic atrophy, and congenital and metabolic disorders, even in cases with vague clinical manifestations. These findings confirm the high diagnostic yield of muscle biopsies, especially as new techniques have been introduced such as immunohistochemistry. Muscle pathology is difficult and emphasizes the importance of this service being undertaken by specialized laboratories with an experienced staff. Microscopical examination of muscle biopsies should be based on adequate clinical information, demonstrating the necessity of close contact between pathologists and referring physicians.

Place, publisher, year, edition, pages
2009. Vol. 114, no 1, 41-45 p.
National Category
Clinical Laboratory Medicine
Research subject
URN: urn:nbn:se:uu:diva-171213DOI: 10.1080/03009730802604949PubMedID: 19242871OAI: oai:DiVA.org:uu-171213DiVA: diva2:510319
Available from: 2012-03-15 Created: 2012-03-15 Last updated: 2012-03-16Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed
In the same journal
Upsala Journal of Medical Sciences
Clinical Laboratory Medicine

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 177 hits
ReferencesLink to record
Permanent link

Direct link