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Systematic appraisal using immunohistochemistry of brain pathology in aged and demented subjects.
Department of Neuroscience and Neurology, University of Kuopio Finland .
2008 (English)In: Dementia and Geriatric Cognitive Disorders, ISSN 1420-8008, E-ISSN 1421-9824, Vol. 25, no 5, 423-32 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND/AIMS: Abnormal processing of hyperphosphorylated tau (HPtau), amyloid-beta (Abeta) and alpha-synuclein (alphaS) proteins is considered as causative with regard to the clinical symptoms in age-related neurodegenerative diseases.

METHODS: In this retrospective, postmortem study applying immunohistochemical methodology, we assessed Alzheimer's-disease (AD)-related HPtau and Abeta pathology in 178 subjects with alphaS pathology.

RESULTS: These pathologies were frequently seen concomitantly, i.e. HPtau in 83% and Abeta in 62% of the alphaS-positive cases. Furthermore, the striatum was frequently involved, particularly in subjects with cognitive impairment (65%). The predictive value of widespread HPtau pathology, i.e. stages V-VI, with respect to cognitive impairment was high, since all 18 subjects presenting with this stage were demented. In contrast, the predictive value of widespread alphaS pathology, i.e. stages 5-6 according to Braak's Parkinson disease staging, was debatable. Fifty-three percent of the subjects with widespread alphaS pathology and no or mild AD-related HPtau pathology were cognitively unimpaired. It is noteworthy that striatal Abeta pathology was more often seen in demented subjects independently of HPtau and/or alphaS status.

CONCLUSION: The causative pathology in subjects with clinically diagnosed dementia with Lewy bodies needs to be clarified in future studies.

Place, publisher, year, edition, pages
2008. Vol. 25, no 5, 423-32 p.
National Category
Clinical Laboratory Medicine
Research subject
URN: urn:nbn:se:uu:diva-171355DOI: 10.1159/000122963PubMedID: 18391488OAI: oai:DiVA.org:uu-171355DiVA: diva2:510636
Available from: 2012-03-17 Created: 2012-03-17 Last updated: 2016-05-13

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