uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Increased expression of caspase 2 in experimental and human temporal lobe epilepsy.
Department of Neuroscience and Neurology, University of Kuopio Finland .
Show others and affiliations
2007 (English)In: Neuromolecular medicine, ISSN 1535-1084, E-ISSN 1559-1174, Vol. 9, no 2, 129-44 p.Article in journal (Refereed) Published
Abstract [en]

Temporal lobe epilepsy (TLE) is often caused by a neurodegenerative brain insult that triggers epileptogenesis, and eventually results in spontaneous seizures, i.e., epilepsy. Understanding the mechanisms of cell death is a key for designing new drug therapies for preventing the neurodegeneration associated with TLE. Here, we investigated the expression of caspase 2, a protein involved in programmed cell death, during the course of epilepsy. We investigated caspase 2 expression in hippocampal samples derived from patients operated on for drug refractory TLE. To understand the evolution of altered-caspase 2 expression during the epileptic process, we also examined caspase 2 expression and activity in the rat hippocampus after status epilepticus-induced acute damage, during epileptogenesis, and after the onset of epilepsy. Caspase 2 expression was enhanced in the hippocampal neurons in chronic TLE patients. In rats, status epilepticus-induced caspase 2 labeling paralleled the progression of neurodegeneration. Proteolytic activation and cleavage of caspase 2 was also detected in the rat brain undergoing epileptogenesis. Our data suggest that caspase 2-mediated programmed cell death participates in the seizure-induced degenerative process in experimental and human TLE.

Place, publisher, year, edition, pages
2007. Vol. 9, no 2, 129-44 p.
National Category
Clinical Laboratory Medicine
Research subject
URN: urn:nbn:se:uu:diva-171367PubMedID: 17627033OAI: oai:DiVA.org:uu-171367DiVA: diva2:510646
Available from: 2012-03-17 Created: 2012-03-17 Last updated: 2016-05-13

Open Access in DiVA

No full text

In the same journal
Neuromolecular medicine
Clinical Laboratory Medicine

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 176 hits
ReferencesLink to record
Permanent link

Direct link