Oral contraceptive and progestin-only use correlates to tissue tumor marker expression in women with cervical intraepithelial neoplasia
2012 (English)In: Contraception, ISSN 0010-7824, E-ISSN 1879-0518, Vol. 85, no 3, 288-293 p.Article in journal (Refereed) Published
Background: The study was conducted to investigate correlations between combined oral contraceptive (COC), any progestin-only contraceptive, medicated intrauterine device (MID) or systemic progestin-only (Syst-P) use and tumor marker expression in cervical intraepithelial neoplasia compared to nonusers.
Study Design: One-hundred ninety-five women of fertile age with cervical biopsies ranging histologically from normal epithelium to carcinoma in situ were recruited consecutively. Combined oral contraceptive, Syst-P and MID users were investigated according to the expression of 11 tumor markers.
Results: Overexpression of cyclooxygenase-2 (Cox-2) was observed in COC users, while interleukin 10 was underexpressed. When users of progestogen-only contraceptives were analyzed, there was a lower expression of cytokeratin 10 and interleukin 10. When only MID users were analyzed, a high expression of p53 was found. Expression of Cox-2, p53 and retinoblastoma protein differed between COC and MID users.
Conclusion: The study showed molecular alterations, which, in general, have not been studied previously in COC users and have never been studied in progestogen-only users. These biological events might be involved in epidemiological correlations found between hormonal contraceptive use and cervical neoplasms.
Place, publisher, year, edition, pages
2012. Vol. 85, no 3, 288-293 p.
Cervical intraepithelial neoplasia, Oral contraceptives, Gestagen, Medicated intrauterine device, Biological markers
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-171406DOI: 10.1016/j.contraception.2011.09.001ISI: 000300387500012OAI: oai:DiVA.org:uu-171406DiVA: diva2:511118