High-resolution three-dimensional probes of biomaterials and their interfaces
2012 (English)In: Philosophical Transactions. Series A: Mathematical, physical, and engineering science, ISSN 1364-503X, Vol. 370, no 1963, 1337-1351 p.Article in journal (Refereed) Published
Interfacial relationships between biomaterials and tissues strongly influence the success of implant materials and their long-term functionality. Owing to the inhomogeneity of biological tissues at an interface, in particular bone tissue, two-dimensional images often lack detail on the interfacial morphological complexity. Furthermore, the increasing use of nanotechnology in the design and production of biomaterials demands characterization techniques on a similar length scale. Electron tomography (ET) can meet these challenges by enabling high-resolution three-dimensional imaging of biomaterial interfaces. In this article, we review the fundamentals of ET and highlight its recent applications in probing the three-dimensional structure of bioceramics and their interfaces, with particular focus on the hydroxyapatite-bone interface, titanium dioxide-bone interface and a mesoporous titania coating for controlled drug release.
Place, publisher, year, edition, pages
2012. Vol. 370, no 1963, 1337-1351 p.
electron tomography, interface, hydroxyapatite, bone, titanium dioxide, implant interface
Engineering and Technology
Research subject Engineering Science with specialization in Materials Science
IdentifiersURN: urn:nbn:se:uu:diva-171539DOI: 10.1098/rsta.2011.0253ISI: 000300631900004OAI: oai:DiVA.org:uu-171539DiVA: diva2:511366