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The use of PIB-PET as a dual pathological and functional biomarker in AD
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Physiology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Biomedical Radiation Sciences.
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - BMC, Physical Organic Chemistry.
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2012 (English)In: Biochimica et Biophysica Acta - Molecular Basis of Disease, ISSN 0925-4439, Vol. 1822, no 3, 380-385 p.Article in journal (Refereed) Published
Abstract [en]

Amyloid imaging with positron emission tomography (PET) is presently used in Alzheimer's disease (AD) research. In this study we investigated the possibility to use early frames (ePIB) of the PIB scans as a rough index of CBF by comparing normalised early PIB values with cerebral glucose metabolism (rCMRglc). PIB-PET and FDG-PET were performed in 37 AD patients, 21 subjects with mild cognitive impairment (MCI) and 6 healthy controls (HC). The patients were divided based on their PIB retention (amyloid load) as either PIB positive (PIB+) or PIB negative (PIB-). Data of the unidirectional influx K-1 from a subset of the subjects including 7 AD patients and 3 HC was used for correlative analysis. Data was analysed using regions of interest (ROI) analysis. A strong, positive correlation was observed across brain regions between K-1 and ePIB (r=0.70: p <= 0.001). The ePIB values were significantly lower in the posterior cingulate (p <= 0.001) and the parietal cortices (p = 0.002) in PIB+ subjects compared to PIB-, although the group difference were stronger for rCMRglc in cortical areas (p <= 0.001). Strong positive correlations between ePIB and rCMRglc were observed in all cortical regions analysed, especially in the posterior cingulate and parietal cortices (p <= 0.001). A single dynamic PIE-PET scan may provide information about pathological and functional changes (amyloidosis and impaired blood flow). This might be important for diagnosis of AD, enrichment of patients in clinical trials and evaluation of treatment effects.

Place, publisher, year, edition, pages
2012. Vol. 1822, no 3, 380-385 p.
Keyword [en]
PIB, Positron emission tomography (PET), Alzheimer's disease (AD), Cerebral blood flow, Cerebral glucose metabolism, Mild Cognitive Impairment (MCI)
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-171665DOI: 10.1016/j.bbadis.2011.11.006ISI: 000300807000009OAI: oai:DiVA.org:uu-171665DiVA: diva2:512266
Available from: 2012-03-27 Created: 2012-03-25 Last updated: 2012-03-27Bibliographically approved

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Engler, HenryBlomquist, GunnarLångström, Bengt
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