RNA interference of Hemolin causes depletion of phenoloxidase activity in Hyalophora cecropia
2007 (English)In: Developmental and Comparative Immunology, ISSN 0145-305X, E-ISSN 1879-0089, Vol. 31, no 6, 571-575 p.Article in journal (Refereed) Published
Melanization is regulated by the prophenoloxidase cascade and functions as a response to intruding microorganisms in invertebrates. When injecting dsRNA of the lepidopteran immune protein hemolin in pupae of Hyalophora cecropia (Lepidoptera: Saturniidae), we observed a significant reduction in phenoloxidase activity after 24 h, but not after 72 h. The link between hemolin and the prophenoloxidase system suggests that hemolin is a pattern recognition protein important for the triggering of the prophenoloxidase cascade in the defence against bacterial infections.
Place, publisher, year, edition, pages
2007. Vol. 31, no 6, 571-575 p.
Hemolin, Hyalophora cecropia, Phenoloxidase, RNA interference
IdentifiersURN: urn:nbn:se:uu:diva-23459DOI: 10.1016/j.dci.2006.09.006ISI: 000244761000004PubMedID: 17129606OAI: oai:DiVA.org:uu-23459DiVA: diva2:51233