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RNA interference of Hemolin causes depletion of phenoloxidase activity in Hyalophora cecropia
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Physiology and Developmental Biology, Comparative Physiology.
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2007 (English)In: Developmental and Comparative Immunology, ISSN 0145-305X, E-ISSN 1879-0089, Vol. 31, no 6, 571-575 p.Article in journal (Refereed) Published
Abstract [en]

Melanization is regulated by the prophenoloxidase cascade and functions as a response to intruding microorganisms in invertebrates. When injecting dsRNA of the lepidopteran immune protein hemolin in pupae of Hyalophora cecropia (Lepidoptera: Saturniidae), we observed a significant reduction in phenoloxidase activity after 24 h, but not after 72 h. The link between hemolin and the prophenoloxidase system suggests that hemolin is a pattern recognition protein important for the triggering of the prophenoloxidase cascade in the defence against bacterial infections.

Place, publisher, year, edition, pages
2007. Vol. 31, no 6, 571-575 p.
Keyword [en]
Hemolin, Hyalophora cecropia, Phenoloxidase, RNA interference
National Category
Biological Sciences
URN: urn:nbn:se:uu:diva-23459DOI: 10.1016/j.dci.2006.09.006ISI: 000244761000004PubMedID: 17129606OAI: oai:DiVA.org:uu-23459DiVA: diva2:51233
Available from: 2008-05-15 Created: 2008-05-15 Last updated: 2011-02-10Bibliographically approved

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Söderhäll, Kenneth
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