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DNA-assisted protein detection technologies
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Molecular tools. Uppsala University, Science for Life Laboratory, SciLifeLab. (Landegren)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Molecular tools. Uppsala University, Science for Life Laboratory, SciLifeLab. (Landegren)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Molecular tools. Uppsala University, Science for Life Laboratory, SciLifeLab. (Landegren)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Molecular tools. Uppsala University, Science for Life Laboratory, SciLifeLab. (Landegren)
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2012 (English)In: Expert Review of Proteomics, ISSN 1478-9450, E-ISSN 1744-8387, Vol. 9, no 1, 21-32 p.Article, review/survey (Refereed) Published
Abstract [en]

Improved protein assays promise to offer new insights into biological processes as well as the identification of new, clinically important biomarkers. In recent years, a number of approaches have been developed where protein-binding reagents, typically antibodies, are equipped with DNA strands to enable protein analyses via powerful nucleic acid detection reactions for improved performance. In this review, we provide a background to this emerging field, and we describe several different ways in which these reagents can improve protein analyses by lowering detection thresholds, improving multiplexing and extending the range of biomolecules available for analysis, both in research settings and in clinical routine.

Place, publisher, year, edition, pages
2012. Vol. 9, no 1, 21-32 p.
Keyword [en]
antibody-DNA conjugates, DNA amplification, immuno-PCR, immuno-RCA, protein biomarkers, protein detection, proximity extension assay, proximity ligation assay
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-171838DOI: 10.1586/EPR.11.78ISI: 000300918400009OAI: oai:DiVA.org:uu-171838DiVA: diva2:512524
Available from: 2012-03-28 Created: 2012-03-28 Last updated: 2017-12-07Bibliographically approved

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Nong, Rachel YuanGu, JijuanDarmanis, SpyrosKamali-Moghaddam, MasoodLandegren, Ulf

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Nong, Rachel YuanGu, JijuanDarmanis, SpyrosKamali-Moghaddam, MasoodLandegren, Ulf
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Molecular toolsScience for Life Laboratory, SciLifeLab
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Expert Review of Proteomics
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