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Quartz crystal microbalance bioaffinity sensor for rapid identification of glycosyldisulfide lectin inhibitors from a dynamic combinatorial library
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Solid State Electronics.
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2006 (English)In: Biosensors & bioelectronics, ISSN 0956-5663, E-ISSN 1873-4235, Vol. 22, no 1, 42-48 p.Article in journal (Refereed) Published
Abstract [en]

Carbohydrate-lectin,interactions were probed with dynamic combinatorial libraries, using the plant lectin Concanavalin A as target species. The dynamic combinatorial libraries were generated from a pool of thiol components through reversible thiol-disulfide interchange, and screened using a simple and efficient method based on a quartz crystal microbalance setup. It was found that dimers based on 1-thio- and 6-thin-mannose analogues were the most active inhibitors. Furthermore, the results clearly show that the 6-thio-mannose possess unique characteristics compared to its oxygen-containing counterpart.

Place, publisher, year, edition, pages
2006. Vol. 22, no 1, 42-48 p.
Keyword [en]
quartz crystal microbalance, dynamic combinatorial chemistry, glycochemistry, carbohydrates, lectins, molecular recognition
National Category
Engineering and Technology
URN: urn:nbn:se:uu:diva-23513DOI: 10.1016/j.bios.2005.11.024ISI: 000241040600006OAI: oai:DiVA.org:uu-23513DiVA: diva2:51287
Available from: 2007-01-30 Created: 2007-01-30 Last updated: 2011-06-01Bibliographically approved

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Anderson, Henrik
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