The number of unrecognized myocardial infarction scars detected at DE-MRI increase during a 5-year follow-up
(English)Manuscript (preprint) (Other academic)
In the population-based Prospective Investigation of the Vasculature in Uppsala Seniors study, an unexpected high prevalence of unrecognized myocardial infarction (UMI) scars were found at delayed enhanced cardiac MRI (DE-MRI). We now investigated if UMI scars detected with DE-MRI at age 70 would still be detectable at age 75 and how their prevalence and size change over time.
In the 248 participants that underwent DE-MRI at age 70, 185 subjects underwent a follow-up scan at age 75. At both instances, a myocardial infarction (MI) scar was defined as delayed-enhancement involving the subendocardial layer.
In the 184 subjects that underwent follow-up, 42 subjects had an UMI scar at age 70 and 61 at age 75. Thirty-seven (88%) of the 42 UMI scars seen at age 70 were still seen in the same myocardial segment at age 75 and 3 (7%) of the subjects with an UMI scar at age 70 displayed a new RMI scar in the same segment at age 75. Twenty-four of the 140 subjects with no MI scar at age 70 developed a UMI scar after 5 years. The scar mass of subjects with UMI scars at both examinations did not change during follow-up (mean 3.8g; range 0.2-26g vs. mean 3.9g; range 0.1-27g).
The prevalence of UMI scars detected at DE-MRI increases with age. During a 5-year follow-up, 88% (37/42) of the UMI scars were still visible in the same myocardial segment reassuring that UMI scars are a consistent finding. The nature and prognostic impact of UMIs in the general population are however yet unknown.
Unrecognized myocardial infarction; delayed-enhancement magnetic resonance imaging; follow-up study; epidemiology
Radiology, Nuclear Medicine and Medical Imaging Cardiac and Cardiovascular Systems
Research subject Radiology; Cardiology; Epidemiology
IdentifiersURN: urn:nbn:se:uu:diva-172069OAI: oai:DiVA.org:uu-172069DiVA: diva2:513403