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Self-reported differences in side-effects for 110 heroin addicts during opioid addiction and during methadone treatment
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Psychiatry, University Hospital.
2011 (English)In: Heroin addiction and related clinical problems, ISSN 1592-1638, Vol. 13, no 4, 5-12 p.Article in journal (Refereed) Published
Abstract [en]

Although methadone maintenance treatment (MMT) has been shown to be effective, poor compliance is always a threat. It has often been pointed out that one variable that inevitably reduces adherence to treatment regimes is the negative side-effects of the treatment. This study examines seventeen known side-effects in a sample of 110 former opiate addicts consecutively admitted to methadone maintenance treatment. Self-reported side-effects were collected through a questionnaire. Despite the considerable increase, from 23 to 74% of the sample, in the proportion that reported individual side-effects between the period of opiate use and that of methadone treatment, the overall result was a significant decrease in eleven symptoms, no change in four and a substantial increase in only two. In some individuals a symptom that is liable to be problematic actually does become problematic, while the same symptom becomes less frequent in the group as a whole. Weight gain is the symptom that increases most in the whole group and needs to be constantly monitored. Other side-effects that remain high and need to be kept under review in clinical practice are nervousness, decreased libido, daytime drowsiness, constipation and perspiration.

Place, publisher, year, edition, pages
2011. Vol. 13, no 4, 5-12 p.
Keyword [en]
Methadone, Opioid use, Side-effects, Symptom complaints
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-172174ISI: 000301097000001OAI: oai:DiVA.org:uu-172174DiVA: diva2:513650
Available from: 2012-04-03 Created: 2012-04-02 Last updated: 2012-04-03Bibliographically approved

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Grönbladh, Leif
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Psychiatry, University Hospital
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