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ULIMORELIN Ghrelin (GHS) Receptor Agonist Treatment of Postoperative Ileus Treatment of Gastroparesis
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
2011 (English)In: Drugs of the future, ISSN 0377-8282, E-ISSN 2013-0368, Vol. 36, no 12, 899-907 p.Article in journal (Refereed) Published
Abstract [en]

Hunger contractions consist of a series of strong contractions of the stomach that evolve to phase Ill of the migrating motor complex and move down the small intestine. Ghrelin is considered to be important for the initiation of hunger contractions and promotes gastric emptying. Other gastrointestinal endocrine and neuronal systems play powerful supplementary roles in the development of hunger. Macrocyclic template chemistry (MATCH (TM)) has produced the macrocyclic peptidomimetic ulimorelin (TZP-101). By an action selectively directed to the ghrelin receptor, this peptide analogue has been shown to be able to stimulate gastric emptying in diabetic gastroparesis and relieve the associated symptom burden in gastroparesis, predominantly nausea and vomiting. Ulimorelin has also been shown to be effective in reducing postoperative ileus in colectomy. These effects are not associated with any serious adverse events. As ulimorelin opens up new indications for treatment, this will strengthen the possibility of relieving patients of symptoms related to stasis of contents in the upper gastrointestinal tract. Thus, ulimorelin is a promising pharmaceutical that should activate gastrointestinal regulatory systems in disorders associated with gastric hypomotility.

Place, publisher, year, edition, pages
2011. Vol. 36, no 12, 899-907 p.
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Medical and Health Sciences
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URN: urn:nbn:se:uu:diva-172173DOI: 10.1358/dof.2011.36ISI: 000301210900004OAI: oai:DiVA.org:uu-172173DiVA: diva2:513678
Available from: 2012-04-03 Created: 2012-04-02 Last updated: 2017-12-07Bibliographically approved

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Hellström, Per

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