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Bilateral cataract induced by unilateral UVR-B exposure: evidence for an inflammatory response
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2013 (English)In: Acta Ophthalmologica, ISSN 1755-375X, E-ISSN 1755-3768, Vol. 91, no 3, 236-242 p.Article in journal (Refereed) Published
Abstract [en]

Purpose: To investigate whether unilateral in vivo UVR-B exposure of one eye affects the fellow eye in a co-cataractogenic, sympathetic reaction and to determine whether an inflammatory response could be involved in the pathogenesis.

Methods: C57BL/6 mice were unilaterally exposed in vivo to UVR-B for 15 min. In the group of 24 animals each received 0×/2×/3×/or 4× cataract threshold equivalent dose. Following 48-hr UVR-B exposure, cataract morphology was documented in dark-field illumination photography, and light scattering was quantified, in both lenses in vitro. Serum levels of pro-inflammatory cytokines IL-1ß, IL-6 and TNF-α were analysed with ELISA. Immunohistochemistry was performed for inflammatory infiltration in exposed and contralateral eyes.

Results: UVR-B exposure induced cataract in all exposed lenses. There was additionally a significant UVR dose-dependent increase in light scattering in the lenses of the non-exposed fellow eye. Inflammatory infiltration was detected immunohistochemically in the anterior segment of both eyes. IL-1β serum concentration increased with increasing UVR-B exposure dose. There was a similar trend for serum IL-6 but not for TNF-α.

Conclusion: Unilateral UVR-B exposure to one eye is associated with intraocular inflammation and an increase in lens light scattering also in the unexposed, fellow eye. A resulting systemic inflammatory response might be mediated by IL-1β and possibly IL-6. The finding that an inflammatory response may play a role in UVR-B-induced cataract development might initiate new strategies in the prevention of the disease.

Place, publisher, year, edition, pages
2013. Vol. 91, no 3, 236-242 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-172274DOI: 10.1111/j.1755-3768.2012.02384.xISI: 000317983000028PubMedID: 22458592OAI: oai:DiVA.org:uu-172274DiVA: diva2:513780
Available from: 2012-04-03 Created: 2012-04-03 Last updated: 2017-12-07Bibliographically approved

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Söderberg, Per

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