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Neuroprotection by S-PBN in hyperglycemic ischemic brain injury
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care.
2011 (English)In: Coronary artery disease: 2011 update: Proceedings of the 9th International Congress onCoronary Artery Disease / [ed] Basil S. Lewis, Moshe Y. Fugelman, David A. Halon, Bologna: Medimond, 2011, 41-43 p.Conference paper, Published paper (Refereed)
Abstract [en]

Background: Hyperglycemia exacerbates focal ischemic brain damage supposedly through various mechanisms. One such mechanism is oxidative stress involving reactive oxygen and nitrogen species (RONS) production. Nitrones attenuate oxidative stress in various models of brain injury. Sulphonated nitrones are hydrophilic and highly feasible to administer in experimental settings. Sodium 2-sulfophenyl-N-tert-butyl nitrone (S-PBN) has been shown neuroprotective in experimental brain trauma. Together with the theories on increased oxidative stress in focal brain ischemia with concomitant hyperglycemia, we hypothesised that S-PBN might be neuroprotective under those circumstances as well.

Material and methods: The rats were made hyperglycemic by intraperitoneal bolus of glucose (2 g/kg) and then subjected to 90 min transient middle cerebral artery occlusion (MCAO). They were randomised to a therapeutic regime of S-PBN (47 mg/kg) or saline given intravenously. Neurological testing and tetrazolium red staining were performed after 1 day.

Results: S-PBN improved the neurological performance at day 1 both in Bederson score (1,3 +/- 0,8 vs. 2,7 +/- 0,48)(figure 1) and on the inclined plane [74,5% +/- 4,6 (S-PBN) vs. 66% +/- 8,3 (control) P< 0.05] (figure 2); but did not reduce the infarct size (figure 3). Physiological data did not differ between groups (table1).

Place, publisher, year, edition, pages
Bologna: Medimond, 2011. 41-43 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-172309ISI: 000300222000008ISBN: 978-88-7587-619-7 (print)OAI: oai:DiVA.org:uu-172309DiVA: diva2:513960
Conference
9th International Congress on Coronary Artery Disease ICCAD 2011, Venice Italy, October 23-26 2011
Available from: 2012-04-04 Created: 2012-04-04 Last updated: 2012-04-04Bibliographically approved

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Molnar, MariaLennmyr, Fredrik

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