The primate spliceosomal snRNA transcriptome as revealed by deep sequencing
(English)Manuscript (preprint) (Other academic)
Small nuclear RNAs (snRNAs) in combination with protein factors form the spliceosomes and are essential for pre-mRNA splicing. In this study we have characterized the spliceosomal snRNA (U snRNA) transcriptome in human, chimpanzee and rhesus using a recently developed high-throughput sequencing approach. Our study has revealed that the U snRNA transcriptomes of all three primates have a similar composition and that the vast majority of the U snRNAs originate from a few well-defined loci. We have detected some heterogeneity in the U snRNA transcriptomes that is primarily caused by the presence of SNPs in the few expressed loci that we have identified.
Biochemistry and Molecular Biology
Research subject Molecular Cellbiology
IdentifiersURN: urn:nbn:se:uu:diva-172428OAI: oai:DiVA.org:uu-172428DiVA: diva2:514632