GABA, a natural immunomodulator of T lymphocytes
2008 (English)In: Journal of Neuroimmunology, ISSN 0165-5728, E-ISSN 1872-8421, Vol. 205, no 1-2, 44-50 p.Article in journal (Refereed) Published
gamma-aminobutyric acid (GABA) is the main neuroinhibitory transmitter in the brain. Here we show that GABA in the extracellular space may affect the fate of pathogenic T lymphocytes entering the brain. We examined in encephalitogenic T cells if they expressed functional GABA channels that could be activated by the low (nM-1 microM), physiological concentrations of GABA present around neurons in the brain. The cells expressed the alpha1, alpha4, beta2, beta3, gamma1 and delta GABAA channel subunits and formed functional, extrasynaptic-like GABA channels that were activated by 1 microM GABA. 100 nM and higher GABA concentrations decreased T cell proliferation. The results are consistent with GABA being immunomodulatory.
Place, publisher, year, edition, pages
Elsevier, 2008. Vol. 205, no 1-2, 44-50 p.
GABAA, Tonic current, Inhibition, T cell
IdentifiersURN: urn:nbn:se:uu:diva-172499DOI: 10.1016/j.jneuroim.2008.08.017PubMedID: 18954912OAI: oai:DiVA.org:uu-172499DiVA: diva2:514795