Onset of mucosal, dermal, and general symptoms in relation to biomarkers and exposures in the dwelling: a cohort study from 1992 to 2002
2012 (English)In: Indoor Air, ISSN 0905-6947, E-ISSN 1600-0668, Vol. 22, no 4, 331-338 p.Article in journal (Refereed) Published
We examined the associations between biomarkers of allergy and inflammation, indoor environment in dwellings, and incidence and remission of symptoms included in the sick building syndrome (SBS) and changes in the home environment of 452 adults who were followed from 1992 to 2002 within the Uppsala part of the European Community Respiratory Health Survey (ECRHS). The 10-year incidence (onset) of general, mucosal, and dermal symptoms was 8.5%, 12.7%, and 6.8%, respectively. Dampness or indoor molds at baseline was a predictor of incidence of general (relative risk [RR] = 1.98), mucosal (RR = 2.28), and dermal symptoms (RR = 1.91). Women had higher incidence of general (RR = 1.74) and mucosal symptoms (RR = 1.71). Indoor painting increased the incidence of general symptoms (RR = 1.62). Bronchial responsiveness (BR), eosinophil counts in blood, total IgE and eosinophilic cationic protein (ECP) in serum at baseline were predictors of incidence of SBS. At follow-up, BR, total IgE, and C-reactive protein (CRP ) were associated with increased incidence of SBS. Moreover, subjects with doctor-diagnosed asthma at baseline had a higher incidence of general (RR = 1.65) and mucosal symptoms (RR = 1.97). In conclusion, female gender, dampness or indoor molds, indoor painting, and biomarkers of allergy and inflammation were associated with a higher incidence of SBS symptoms, in particular mucosal symptoms.
Place, publisher, year, edition, pages
John Wiley & Sons, 2012. Vol. 22, no 4, 331-338 p.
Biomarkers, Indoor environment, Longitudinal cohort study, Asthma, Sick building syndrome (SBS), Dwelling
Environmental Health and Occupational Health
Research subject Occupational and Environmental Medicine
IdentifiersURN: urn:nbn:se:uu:diva-172535DOI: 10.1111/j.1600-0668.2012.00766.xISI: 000306223500008PubMedID: 22257085OAI: oai:DiVA.org:uu-172535DiVA: diva2:514899