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Increased phosphate content of fibrinogen  in vivo correlates with alteration in fibrinogen behaviour
Institute of Biochemistry, Glasgow Royal Infirmary, Glasgow, Scotland. (ek pia)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical and Physiological Chemistry. (ek pia)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical and Physiological Chemistry. (ek pia)
Samariterhemmet Uppsala.
1992 (English)In: Thrombosis Research, ISSN 0049-3848, E-ISSN 1879-2472, Vol. 68, no 6, 467-473 p.Article in journal (Refereed) Published
Abstract [en]

Fibrinogen was purified from five patients admitted for hip-replacement surgery the day before (day 0), the day after (day 2) and and one week after the operation (day 8). The behaviour of each patient's three fibrinogens was compared in thrombin gelation assays and plasmin degradation experiments to investigate whether the reported increase in protein-bound phosphate at day 2 and day 8 had any effect on the functional behaviour of fibrinogen as has been demonstrated in vitro. It was found that the thickness of the fibrin fibres produced by thrombin increased markedly at day 2 and declined thereafter. Susceptibility to plasmin appeared to decrease post-operatively by 50% and remained at that level on day 8 despite the phosphate content returning to normal. This has also been shown for fibrinogen phosphorylated in vitro. We conclude, after testing the fibrinogens with and without alkaline phosphatase pretreatment, that our data most resemble the published findings for in vitro phosphorylation of fibrinogen by casein kinase II.

Place, publisher, year, edition, pages
1992. Vol. 68, no 6, 467-473 p.
Keyword [en]
Fibrinogen, phosphoproteins, thrombin, plasmin, acute phase, casein kinase II
National Category
Biochemistry and Molecular Biology
Identifiers
URN: urn:nbn:se:uu:diva-172753DOI: 10.1016/0049-3848(92)90059-JOAI: oai:DiVA.org:uu-172753DiVA: diva2:515550
Available from: 2012-04-13 Created: 2012-04-13 Last updated: 2017-12-07Bibliographically approved

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