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PARP-2 activation and association with Smads during regulation of TGFβ signaling
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(English)Manuscript (preprint) (Other academic)
National Category
Natural Sciences Cell Biology
URN: urn:nbn:se:uu:diva-172853OAI: oai:DiVA.org:uu-172853DiVA: diva2:515831
Available from: 2012-04-16 Created: 2012-04-16 Last updated: 2012-08-01
In thesis
1. Mechanisms for Quantitative Regulation of TGF-ß Signaling
Open this publication in new window or tab >>Mechanisms for Quantitative Regulation of TGF-ß Signaling
2012 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Cancer is a widely spread disease, and many cancer variants are today still difficult to treat. Efforts are being made to understand the complexity of cancer, both at a clinical level but also at a pre-clinical level. The aim is of course to merge the research from both disciplines, as an example, find out how to treat a tumour in a patient and what molecular mechanisms are behind the origin of the tumour. Basic research provides a platform that in the long run will help to create treatments for many cancer variants that exist today. Transforming Growth Factor Beta (TGF-ß) is a cytokine that regulates many cellular events such as cell differentiation, cell proliferation and migration. TGF-ß signaling is important to study since many studies show that patients with cancer actually have accumulated mutations in proteins connected to the pathway. In this thesis I try to enhance the knowledge of the TGF-ß signaling pathway, looking in more detail how the signaling output is regulated by the response to the ligand, explained in paper four. Furthermore I try to reveal the protein network that control transmission of the signal from the cell surface to the nucleus. We found that PARP-1 (paper one and two) and PARP-2 (paper three) associates with the signaling pathway to regulate the Smad proteins and to negatively regulate the transcription of Smad target genes.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2012. 41 p.
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 1651-6206 ; 767
National Category
Natural Sciences Cell Biology
Research subject
Biology with specialization in Molecular Cell Biology
urn:nbn:se:uu:diva-172855 (URN)978-91-554-8351-7 (ISBN)
Public defence
2012-06-07, B42, Biomedical Center (BMC), Husargatan 3, C11, Uppsala, 09:00 (English)
Available from: 2012-05-14 Created: 2012-04-16 Last updated: 2012-08-01Bibliographically approved

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