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Heparanase overexpression reduces carrageenan-induced mechanical and cold hypersensitivity in mice
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.
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2012 (English)In: Neuroscience Letters, ISSN 0304-3940, E-ISSN 1872-7972, Vol. 511, no 1, 4-7 p.Article in journal (Refereed) Published
Abstract [en]

Heparanase controls the structure and functions of extracellular matrix (ECM) by degrading heparan sulfate proteoglycans. Heparanase is involved in inflammatory process through modulating the functions of inflammatory cytokines. The present study aimed to find out whether overexpression of heparanase in mice affects carrageenan-induced localized inflammation and inflammatory hyperalgesia. Without challenge, the heparanase overexpression did not significantly affect the mice in response to mechanical, cold and heat stimulation. Unilateral subcutaneous administration of carrageenan produced hypersensitivity to mechanical and cold in both wildtype and the heparanase overexpression (Hpa-tg) mice 24h after treatment. In comparison to wildtype animals, the Hpa-tg mice showed significantly reduced mechanical and cold hypersensitivity. This may, at least partially, due to the reduced mast cell infiltration at the site of inflammation in Hpa-tg mice. These data support a role for heparanase that reduces localized inflammation and inflammatory hyperalgesia in mice.

Place, publisher, year, edition, pages
2012. Vol. 511, no 1, 4-7 p.
Keyword [en]
Heparanase, Transgenic mice, Nociception, Inflammation, Hyperalgesia
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-172832DOI: 10.1016/j.neulet.2011.12.038ISI: 000301696000002OAI: oai:DiVA.org:uu-172832DiVA: diva2:516192
Available from: 2012-04-17 Created: 2012-04-16 Last updated: 2012-04-17Bibliographically approved

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Zhang, XiaoLi, Jin-Ping
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GeriatricsDepartment of Medical Biochemistry and Microbiology
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