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A mechanism-based integrated pharmacokinetic enzyme model describing the time course and magnitude of phenobarbital-mediated enzyme induction in the rat.
Uppsala University, Medicinska vetenskapsområdet, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
Uppsala University, Medicinska vetenskapsområdet, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
Uppsala University, Medicinska vetenskapsområdet, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
2006 (English)In: Pharm Res, ISSN 0724-8741, Vol. 23, no 3, 521-32 p.Article in journal (Refereed) Published
Place, publisher, year, edition, pages
2006. Vol. 23, no 3, 521-32 p.
Keyword [en]
Animals, Anticonvulsants/*pharmacokinetics/pharmacology, Aryl Hydrocarbon Hydroxylases/biosynthesis/metabolism, Cytochrome P-450 CYP1A2/biosynthesis/metabolism, Cytochrome P-450 CYP2B1/biosynthesis/metabolism, Cytochrome P-450 Enzyme System/biosynthesis/*metabolism, Enzyme Induction, Liver/drug effects/enzymology, Male, Microsomes; Liver/enzymology, Models; Biological, Phenobarbital/*pharmacokinetics/pharmacology, Rats, Rats; Sprague-Dawley
Identifiers
URN: urn:nbn:se:uu:diva-23893PubMedID: 16525862OAI: oai:DiVA.org:uu-23893DiVA: diva2:51667
Available from: 2007-02-01 Created: 2007-02-01 Last updated: 2011-01-11

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Magnusson, Mats OKarlsson, Mats OSandström, Rikard

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