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A semimechanistic-physiologic population pharmacokinetic/pharmacodynamic model for neutropenia following pemetrexed therapy.
Uppsala University, Medicinska vetenskapsområdet, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
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2006 (English)In: Cancer Chemother Pharmacol, ISSN 0344-5704, Vol. 57, no 4, 412-26 p.Article in journal (Refereed) Published
Place, publisher, year, edition, pages
2006. Vol. 57, no 4, 412-26 p.
Keyword [en]
Adult, Aged, Algorithms, Analysis of Variance, Antimetabolites; Antineoplastic/administration & dosage/*adverse effects/*pharmacokinetics, Area Under Curve, Avitaminosis/metabolism, Blood Cell Count, Body Surface Area, Clinical Trials; Phase II, Data Interpretation; Statistical, Female, Folic Acid/therapeutic use, Glutamates/administration & dosage/*adverse effects/*pharmacokinetics, Guanine/administration & dosage/adverse effects/*analogs & derivatives/pharmacokinetics, Humans, Infusions; Intravenous, Leukocyte Count, Male, Middle Aged, Models; Statistical, Neutropenia/*chemically induced/epidemiology/prevention & control, Neutrophils/physiology, Population, Vitamin B 12/therapeutic use, Vitamin B 6/therapeutic use, Vitamins/therapeutic use
URN: urn:nbn:se:uu:diva-23896PubMedID: 16322990OAI: oai:DiVA.org:uu-23896DiVA: diva2:51670
Available from: 2007-02-01 Created: 2007-02-01 Last updated: 2011-01-11

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Karlsson, Mats O
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