Peptide fragments of myelin basic protein as substrates of protein kinase C.
1992 (English)In: Biochemistry International, ISSN 0158-5231, Vol. 27, no 4, 625-631 p.Article in journal (Refereed) Published
A set of peptides derived from myelin basic protein was synthesized and the kinetics of their phosphorylation by protein kinase C was studied. The replacement or the removal of the N-terminal Gln had no effect on the activity of the parent peptide. The removal of the following Lys or Arg led to a systematic decrease in substrate activity. The modifications in the C-terminal part of the peptide had a weaker influence on the parameters Vmax and KM than those in the N-terminal. The rather regular dependence of the activity of substrates upon their structure does not allow the strict definition of a minimum substrate for protein kinase C.
Place, publisher, year, edition, pages
1992. Vol. 27, no 4, 625-631 p.
Biochemistry and Molecular Biology
IdentifiersURN: urn:nbn:se:uu:diva-173138PubMedID: 1384495OAI: oai:DiVA.org:uu-173138DiVA: diva2:516713