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Long-standing increased bone turnover at the fixation points after anterior cruciate ligament reconstruction: A positron emission tomography (PET) study of 8 patients
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
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2006 (English)In: Acta Orthopaedica, ISSN 1745-3674, E-ISSN 1745-3682, Vol. 77, no 6, 921-925 p.Article in journal (Refereed) Published
Abstract [en]

Background: A secure incorporation of the graft in a bone tunnel is a prerequisite for successful anterior cruciate ligament reconstruction. In this cross-sectional pilot study, we studied the healing process with positron emission tomography (PET) scanning. Patients and methods: 8 young patients underwent an anterior cruciate ligament reconstruction with a bonepatellar tendon-bone graft (BTB, n = 4) or a quadruple semitendinosus and gracilis graft (ST/G, n = 4). Regional bone turnover was quantified with an 18F-fluoride PET scan in each patient 1 day, 3 weeks, 7 months, or 22 months after surgery. Results: The highest activity level was found 3 weeks after surgery, but the activity at the femoral fixation points was markedly increased even after 7 months. The bone turnover was almost normalized 22 months after the operation. Interpretation: It would take at least 7 months until an anterior cruciate ligament graft, fixed with an interference screw, is completely incorporated. This finding is important for postoperative rehabilitation. Furthermore, PET is a feasible tool when studying new ways of fixing soft tissue to bone.

Place, publisher, year, edition, pages
2006. Vol. 77, no 6, 921-925 p.
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Medical and Health Sciences
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URN: urn:nbn:se:uu:diva-23922DOI: 10.1080/17453670610013231ISI: 000243586300014PubMedID: 17260202OAI: oai:DiVA.org:uu-23922DiVA: diva2:51696
Available from: 2007-02-02 Created: 2007-02-02 Last updated: 2017-12-07Bibliographically approved

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Michaëlsson, KarlRahme, Hans

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