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RNA-Puzzles: A CASP-like evaluation of RNA three-dimensional structure prediction
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2012 (English)In: RNA: A publication of the RNA Society, ISSN 1355-8382, E-ISSN 1469-9001, Vol. 18, no 4, 610-625 p.Article in journal (Refereed) Published
Abstract [en]

We report the results of a first, collective, blind experiment in RNA three-dimensional (3D) structure prediction, encompassing three prediction puzzles. The goals are to assess the leading edge of RNA structure prediction techniques; compare existing methods and tools; and evaluate their relative strengths, weaknesses, and limitations in terms of sequence length and structural complexity. The results should give potential users insight into the suitability of available methods for different applications and facilitate efforts in the RNA structure prediction community in ongoing efforts to improve prediction tools. We also report the creation of an automated evaluation pipeline to facilitate the analysis of future RNA structure prediction exercises.

Place, publisher, year, edition, pages
2012. Vol. 18, no 4, 610-625 p.
Keyword [en]
3D prediction, bioinformatics, force fields, structure
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-173332DOI: 10.1261/rna.031054.111ISI: 000301954600002OAI: oai:DiVA.org:uu-173332DiVA: diva2:517628
Available from: 2012-04-24 Created: 2012-04-23 Last updated: 2012-04-24Bibliographically approved

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Coulbourn Flores, Samuel
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Computational and Systems Biology
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