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The genomic basis of adaptive evolution in threespine sticklebacks
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Uppsala University, Science for Life Laboratory, SciLifeLab.
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2012 (English)In: Nature, ISSN 0028-0836, E-ISSN 1476-4687, Vol. 484, no 7392, 55-61 p.Article in journal (Refereed) Published
Abstract [en]

Marine stickleback fish have colonized and adapted to thousands of streams and lakes formed since the last ice age, providing an exceptional opportunity to characterize genomic mechanisms underlying repeated ecological adaptation in nature. Here we develop a high-quality reference genome assembly for threespine sticklebacks. By sequencing the genomes of twenty additional individuals from a global set of marine and freshwater populations, we identify a genome-wide set of loci that are consistently associated with marine-freshwater divergence. Our results indicate that reuse of globally shared standing genetic variation, including chromosomal inversions, has an important role in repeated evolution of distinct marine and freshwater sticklebacks, and in the maintenance of divergent ecotypes during early stages of reproductive isolation. Both coding and regulatory changes occur in the set of loci underlying marine-freshwater evolution, but regulatory changes appear to predominate in this well known example of repeated adaptive evolution in nature.

Place, publisher, year, edition, pages
2012. Vol. 484, no 7392, 55-61 p.
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Biological Sciences
URN: urn:nbn:se:uu:diva-173320DOI: 10.1038/nature10944ISI: 000302343400033OAI: oai:DiVA.org:uu-173320DiVA: diva2:517659

De två sista författarna delar sistaförfattarskapet. (Kingsley och Lindblad-Toh)

Available from: 2012-04-24 Created: 2012-04-23 Last updated: 2015-02-26Bibliographically approved

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Grabherr, Manfred G.Lindblad-Toh, Kerstin
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