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Coeliac disease and the risk of fractures: A general population-based cohort study
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
(Clinical Research Centre, Örebro University Hospital)
2007 (English)In: Alimentary Pharmacology and Therapeutics, ISSN 0269-2813, E-ISSN 1365-2036, Vol. 25, no 3, 273-285 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Earlier studies have suggested that untreated coeliac disease may be associated with osteoporosis, but results are contradictory for the risk of long-term fractures. AIM: To study the association between coeliac disease and fractures. METHODS: We used Cox regresson to examine the future risk of hip fracture and fracture of any type in more than 13 000 individuals with coeliac disease and 65 000 age- and sex-matched reference individuals in a general population-based cohort. RESULTS: During follow-up, 1365 first hip fractures and 4847 fractures of any type occurred. Coeliac disease was positively associated with subsequent hip fracture (hazard ratio = 2.1; 95% CI = 1.8-2.4) (in children: hazard ratio = 2.6; 95% CI = 1.1-6.2) and fractures of any type (hazard ratio = 1.4; 95% CI = 1.3-1.5) (in children: hazard ratio = 1.1; 95% CI = 1.0-1.2). The absolute excess risk of hip fractures in children with coeliac disease was 4/100 000 person-years. Incidence ratios for hip fracture in individuals with CD were around two both prior to diagnosis of coeliac disease and afterwards; this risk increase remained 20 years after diagnosis of coeliac disease. CONCLUSIONS: Individuals with coeliac disease, including children with coeliac disease, may be at increased risk of hip fracture and fracture of any type. Coeliac disease may be positively associated with long-term hip fracture risk.

Place, publisher, year, edition, pages
2007. Vol. 25, no 3, 273-285 p.
Keyword [en]
Trauma, Diseases of the osteoarticular system, Immunopathology, Intestinal malabsorption, Intestinal disease, Digestive diseases, Cohort study, Human, Public health, Fracture, Epidemiology, Risk factor, Coeliac disease
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-24332DOI: 10.1111/j.1365-2036.2006.03203.xISI: 000243533400005PubMedID: 17269989OAI: oai:DiVA.org:uu-24332DiVA: diva2:52106
Available from: 2007-02-05 Created: 2007-02-05 Last updated: 2011-02-17Bibliographically approved

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