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Microwave-assisted synthesis of small molecules targeting the infectious diseases tuberculosis, HIV/AIDS, malaria and hepatitis C
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry.
2012 (English)In: Organic and biomolecular chemistry, ISSN 1477-0520, E-ISSN 1477-0539, Vol. 10, no 14, 2713-2729 p.Article in journal (Refereed) Published
Abstract [en]

The unique properties of microwave in situ heating offer unparalleled opportunities for medicinal chemists to speed up lead optimisation processes in early drug discovery. The technology is ideal for small-scale discovery chemistry because it allows full reaction control, short reaction times, high safety and rapid feedback. To illustrate these advantages, we herein describe applications and approaches in the synthesis of small molecules to combat four of the most prevalent infectious diseases; tuberculosis, HIV/AIDS, malaria and hepatitis C, using dedicated microwave instrumentation.

Place, publisher, year, edition, pages
2012. Vol. 10, no 14, 2713-2729 p.
National Category
Medical and Health Sciences
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URN: urn:nbn:se:uu:diva-173538DOI: 10.1039/c2ob06833hISI: 000301585600001OAI: oai:DiVA.org:uu-173538DiVA: diva2:523920
Available from: 2012-04-27 Created: 2012-04-26 Last updated: 2017-12-07Bibliographically approved

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Gising, JohanOdell, Luke R.Larhed, Mats

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