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Protein profiling of pancreatic islets
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
2006 (English)In: Expert review of proteomics, ISSN 1478-9450, Vol. 3, no 6, 665-675 p.Article, review/survey (Refereed) Published
Abstract [en]

The insulin-producing beta cell in the islet of Langerhans is central in glucose homeostasis. Its dysfunction is part of the pathogenesis of both Type 1 and 2 diabetes mellitus. In both forms of the disease, there is a cytotoxic component either induced by cytokines, as in Type 1 diabetes, or by elevated levels of glucose and fatty acids, as in Type 2 diabetes. To find the mechanisms responsible for the cytotoxic effects of these compounds proteomic approaches with 2D gel electrophoresis and surface-enhanced laser desorption/ionization time-of-flight mass spectrometry have been undertaken. In this article, we describe these methods, and other methodological aspects of protein profiling of pancreatic islets, and summarize the results obtained with these methods.

Place, publisher, year, edition, pages
2006. Vol. 3, no 6, 665-675 p.
Keyword [en]
Animals, Diabetes Mellitus/epidemiology, Gene Expression Profiling, Humans, Insulin/biosynthesis, Islets of Langerhans/*chemistry/*metabolism, Proteins/*chemistry/*metabolism, Proteomics
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-24720DOI: 10.1586/14789450.3.6.665ISI: 000244235800019PubMedID: 17181479OAI: oai:DiVA.org:uu-24720DiVA: diva2:52494
Available from: 2007-02-07 Created: 2007-02-07 Last updated: 2011-03-29Bibliographically approved

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Ortsäter, HenrikBergsten, Peter

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