The Value of Induction Chemotherapy for Survival in Patients with Non-small Cell Lung Cancer Treated with Radiotherapy
2012 (English)In: Anticancer Research, ISSN 0250-7005, Vol. 32, no 4, 1339-1346 p.Article in journal (Refereed) Published
Aim: The aim of the present study was to retrospectively investigate the impact of induction chemotherapy on treatment outcome in patients treated with curatively intended radiotherapy for non-small cell lung cancer (NSCLC). Patients and Methods: Patients with a diagnosed NSCLC that have been subjected to curatively intended irradiation (>= 50 Gy) and treated in an oncology department in Sweden during the years 1990-2000 were included in the study. Operated patients and patients having received concomitant chemotherapy were excluded. The included patients were localised by a manual search of all the oncology departments' medical records and radiation charts. Results: Patients treated with induction chemotherapy (n=79) had a significantly better overall survival compared with patients treated with radiotherapy alone (p=0.0097) in a univariate Cox regression analysis. A platinum/taxane combination produced the greatest survival benefit; hazard ratio=0.49 (95% confidence interval=0.31 to 0.75). Conclusion: We found that patients treated with induction chemotherapy in addition to radiotherapy for NSCLC have a better overall survival than patients treated with radiotherapy alone and that the best results are achieved using a platinum/taxane combination.
Place, publisher, year, edition, pages
2012. Vol. 32, no 4, 1339-1346 p.
NSCLC, lung cancer, radiotherapy, predictive value, age
Respiratory Medicine and Allergy Cancer and Oncology
IdentifiersURN: urn:nbn:se:uu:diva-173639ISI: 000302492600028OAI: oai:DiVA.org:uu-173639DiVA: diva2:525690