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Autocrine PDGF stimulation in malignancies
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Ludwig Institute for Cancer Research.
2012 (English)In: Upsala Journal of Medical Sciences, ISSN 0300-9734, E-ISSN 2000-1967, Vol. 117, no 2, 83-91 p.Article, review/survey (Refereed) Published
Abstract [en]

Platelet-derived growth factor (PDGF) isoforms are important mitogens for different types of mesenchymal cells, which have important functions during the embryonal development and in the adult during wound healing and tissue homeostasis. In tumors, PDGF isoforms are often over-expressed and contribute to the growth of both normal and malignant cells. This review focuses on tumors expressing PDGF isoforms together with their tyrosine kinase receptors, thus resulting in autocrine stimulation of growth and survival. Patients with such tumors could benefit from treatment with inhibitors of either PDGF or PDGF receptors.

Place, publisher, year, edition, pages
2012. Vol. 117, no 2, 83-91 p.
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Medical and Health Sciences
URN: urn:nbn:se:uu:diva-174018DOI: 10.3109/03009734.2012.658119ISI: 000302949200002PubMedID: 22512244OAI: oai:DiVA.org:uu-174018DiVA: diva2:525871
Available from: 2012-05-09 Created: 2012-05-09 Last updated: 2015-08-10Bibliographically approved

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Heldin, Carl-Henrik
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