Identification and evaluation of potential anti-cancer drugs on human neuroendocrine tumor cell lines
2006 (English)In: Anticancer Research, ISSN 0250-7005, Vol. 26, no 6B, 4125-4129 p.Article in journal (Refereed) Published
The aim of this study was to investigate drug sensitivity in neuroendocrine tumor cell lines. Materials and Methods: In vitro drug sensitivity screening was performed using the fluorometric microculture cytotoxicity assay in one human pancreatic carcinoid and two human bronchial carcinoid cell lines. In addition, a normal human retinal pigment epithelial cell line was used for comparison. A total of 18 drugs with different mechanisms of action were tested. Results: The most active agents were brefeldin A, emetine, bortezomib and idarubicin, having IC50 values < 1 μM in all four cell lines. In addition, the three tumor cell lines showed sensitivity for sanguinarine, Bay11-7085, mitoxantrone, doxorubicin, β-lapachone, NSC 95397 and CGP-74514A. Conclusion: The cell lines were sensitive for several drugs acting in different ways, covering a broad spectrum of mechanisms of action. Some of these compounds may possibly be used in clinical trials and show therapeutic effect in patients with neuroendocrine tumors.
Place, publisher, year, edition, pages
2006. Vol. 26, no 6B, 4125-4129 p.
Drug sensitivity, FMCA, Neuroendocrine tumors
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-24875ISI: 000243040300005PubMedID: 17201123OAI: oai:DiVA.org:uu-24875DiVA: diva2:52649