Bone Engineering by Biomimetic Injectable Hydrogel
2012 (English)In: Molecular Crystals and Liquid Crystals, ISSN 1542-1406, Vol. 555, no 1, 177-188 p.Article in journal (Refereed) Published
Osteoporosis is a multifactorial bone disease characterized by low bone mineral density (BMD) and deterioration of micro-architecture of cancellous bone leading to bone fragility and risk of fractures. In the current work, a novel tissue engineering strategy was experimented to enhance bone architecture in the risk areas via local injection of a biomimetic/osteoinductive injectable hyaluronan based hydrogel loaded with nano-hydroxyapatite crystals (Hya/HA) with/without bone morphogenetic protein (BMP-2), in distal femur of normal and ovariectomized New Zealand white rabbits. Our results revealed the osteoinductive effect of the Hya/HA composite that enhanced bone density and architecture of the rabbit distal femur.
Place, publisher, year, edition, pages
2012. Vol. 555, no 1, 177-188 p.
Bone engineering, hyaluronic acid, hydroxyapatite, injectable hydrogels, osteoinduction, osteoporosis
Medical and Health Sciences Polymer Chemistry
Research subject Chemistry with specialization in Polymer Chemistry
IdentifiersURN: urn:nbn:se:uu:diva-174215DOI: 10.1080/15421406.2012.635530ISI: 000302300400019OAI: oai:DiVA.org:uu-174215DiVA: diva2:526794
11th International Conference on Frontiers of Polymers and Advanced Materials (ICFPAM 2011)