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A unified definition of clinical resistance/intolerance to hydroxyurea in essential thrombocythemia: results of a consensus process by an international working group
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Hematologi)
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2007 (English)In: Leukemia, ISSN 0887-6924, E-ISSN 1476-5551, Vol. 21, no 2, 277-280 p.Article in journal (Refereed) Published
Abstract [en]

A widely accepted definition of resistance or intolerance to hydroxyurea (HU) in patients with essential thrombocythemia (ET) is lacking. An international working group (WG) was convened to develop a consensus formulation of clinically significant criteria for defining resistance/intolerance to HU in ET. To this aim, an analytic hierarchy process (AHP), a multiple-attribute decision-making technique, was used. The steps consisted of selecting the candidate criteria for defining resistance/intolerance; identifying the motivations that could influence the preference of the WG for any individual criterion; comparing the candidate criteria in a pair-wise manner; and grading them according their ability to fulfill the motivations. Every step in the model was derived by questionnaires or group discussion. The WG proposed that the definition of resistance/intolerance should require the fulfillment of at least one of the following criteria: platelet count greater than 600,000/micro l after 3 months of at least 2 g/day of HU (2.5 g/day in patients with a body weight over 80 kg); platelet count greater than 400,000/micro l and WBC less than 2500/micro l or Hb less than 10 g/dl at any dose of HU; presence of leg ulcers or other unacceptable muco-cutaneous manifestations at any dose of HU; HU-related fever.

Place, publisher, year, edition, pages
2007. Vol. 21, no 2, 277-280 p.
Keyword [en]
essential thrombocythemia, hydroxyurea, analytic hierarchy process, resistance, intolerance
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-24970DOI: 10.1038/sj.leu.2404473ISI: 000243729800013PubMedID: 17251900OAI: oai:DiVA.org:uu-24970DiVA: diva2:52744
Available from: 2007-02-08 Created: 2007-02-08 Last updated: 2011-02-16Bibliographically approved

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