Coaxial multi-electrode cell (' O-trap ') for high-sensitivity detection at a multiple frequency in Fourier transform ion cyclotron resonance mass spectrometry: main design and modeling results
2006 (English)In: Rapid Communications in Mass Spectrometry, ISSN 0951-4198, E-ISSN 1097-0231, Vol. 20, no 21, 3223-3228 p.Article in journal (Refereed) Published
Separation of the functions of ion excitation and detection between different cell compartments allows for implementation of excitation and detection techniques unattainable in a single compartment of the conventional ion cyclotron resonance (ICR) cell. In particular, multi-electrode detection at a multiple of the main cyclotron frequency can be utilized without the loss of sensitivity and other negative effects. The new O-trap designed exclusively for ion detection adds an additional, internal coaxial cylinder around which ions with excited cyclotron orbits rotate. Comparison of simulated performance characteristics of the new O-trap with those of the same-size conventional cylindrical cell shows that the O-trap can provide higher sensitivity and ion capacity. Multiplexing of the O-traps can further increase the analysis speed. Future efforts will be aimed at building and testing experimentally the coaxial O-trap, including optimization of the method of ion transfer between the compartments of the cell.
Place, publisher, year, edition, pages
2006. Vol. 20, no 21, 3223-3228 p.
Medical and Health Sciences Biological Sciences Engineering and Technology
IdentifiersURN: urn:nbn:se:uu:diva-24990DOI: 10.1002/rcm.2724ISI: 000241627000010PubMedID: 17019671OAI: oai:DiVA.org:uu-24990DiVA: diva2:52764