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Right ventricular myocardial isovolumic relaxation time and pulmonary pressure
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (UCR)
2006 (English)In: Clinical Physiology and Functional Imaging, ISSN 1475-0961, E-ISSN 1475-097X, Vol. 26, no 1, 1-8 p.Article in journal (Refereed) Published
Abstract [en]

AIMS: Non-invasive assessment of pulmonary artery systolic pressure (PASP) has several limitations. As previously described by Burstin, the right ventricular (RV) isovolumic relaxation time (IVRt) is sensitive to changes in PASP. We therefore compared RV myocardial IVRt, derived by Doppler tissue imaging (DTI), with simultaneously measured invasive PASP. METHODS AND RESULTS: Twenty-six consecutive patients (18 males, mean age 52 +/- 12 years, range 23-75) underwent a simultaneous Doppler echocardiography, including DTI, and cardiac catheterization examination for measurement of PASP and right atrial mean pressures. IVRt was measured using the myocardial velocities by pulsed DTI at both basal and mid cavity segments of the RV free wall. As diastolic time intervals are influenced by heart rate IVRt was corrected for heart rate (IVRt/RR%). A significant correlation was found between PASP and regional IVRt/RR% at both the basal (r = 0.42, P<0.05) and mid cavity segment (r = 0.71, P<0.001). Furthermore, when only patients with normal right atrial pressures (<7 mmHg) were taken into account, the correlation coefficient improved at both basal and mid cavity segments (r = 0.74, P<0.05 and r = 0.83, P<0.01). CONCLUSION: Pulsed Doppler-derived IVRt correlates well with PASP. The use of pulsed DTI for measurement of IVRt is simple, reproducible and easy to obtain. We propose this method as an additional non-invasive tool in the assessment of PASP.

Place, publisher, year, edition, pages
2006. Vol. 26, no 1, 1-8 p.
Keyword [en]
Adult, Aged, Blood Pressure/physiology, Diagnostic Techniques; Cardiovascular, Diastole/*physiology, Echocardiography; Doppler; Pulsed, Feasibility Studies, Female, Heart Catheterization, Heart Diseases/physiopathology/ultrasonography, Hemodynamic Processes, Humans, Male, Middle Aged, Nomograms, Pulmonary Artery/physiology/*physiopathology, Time Factors, Ventricular Dysfunction; Right/physiopathology/ultrasonography, Ventricular Function; Right/*physiology
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-25017DOI: 10.1111/j.1475-097X.2005.00639.xPubMedID: 16398663OAI: oai:DiVA.org:uu-25017DiVA: diva2:52791
Available from: 2007-02-28 Created: 2007-02-28 Last updated: 2010-05-19Bibliographically approved

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Publisher's full textPubMedhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=16398663&dopt=Citation

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